Endocrine Abstracts

Obesity is usually considered to be a forerunner to insulin resistance (IR). Using in vitro studies, we have identified a role for the giant protein AHNAK in regulating Glut4 expression and function. Ex vivo analysis of white adipose tissue from ob/ob mice and aged/obese rats exhibited elevated AHNAK protein levels (2.3- and 3- fold) with concomitant reduction in Glut4 levels (5- and 2-fold).The aim of this study was to investigate the ...